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In addition to the core Double-Take Availability requirements, use these requirements for ESX to ESX protection.
ESX 4.0.x or 4.1 Standard, Advanced, Enterprise, or Enterprise Plus
The ESX versions listed are commonly referred to as the Classic edition. The ESXi versions, commonly referred to as the Embedded and Installable edition, are not supported for ESX to ESX protection.
If your source and target are running on different versions of ESX, ideally, the target should be a newer version of ESX. If your source must be a newer version of ESX than the target, you must take into consideration ESX features that are supported on the newer version on the source (like VmxNet enhanced or additional virtual NICs available) that will not be supported on the earlier target version of ESX
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VirtualCenter—Although VirtualCenter is not required, it is recommended. If you are using it, then you must use version 2.5 or later.
VMotion is only supported if you are using VirtualCenter.
Do not use MSDE for the VirtualCenter database.