In addition to the general application requirements, you must also meet the following requirements to protect Exchange.
Security—By default, the Double-Take service is configured to use the local system account. If you are protecting Exchange, you cannot change this configuration.
If you are protecting Exchange in a 2008 R2 domain where the domain functional level is set to R2, you must grant two levels of access to the local system account on the target. First, grant the Administer information store control to the target in the Configuration Naming Context in order to move users during failover. Second, grant Full control to the target in the Domain Naming Context in order to move Service Principal Names, which will allow users to access their e-mail after a failover.