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If you will be protecting your entire server, there are no separate source or target server requirements. However, the general source and target requirements are high-level requirements that each server must meet for the full-server functionality. A target server may meet these requirements but may not be suitable to stand-in for a source in the event of a source failure. See Finding a compatible target for additional information regarding an appropriate target server for your source.
There is one limitation for full-server protection of a cluster. Microsoft clusters identify disks by their disk signature, which is stored on the physical disk in the master boot record. When Double-Take Availabilityis used to failover a cluster node, the disk signature of the target will be different than the source and the cluster will fail to start. Therefore, Double-Take Availability does not natively support the full-server protection of Microsoft cluster nodes. However, you can alter the disk signature on the target manually. See the Microsoft Knowledge Base article 280425 for details on how to change the disk signature.
If you are using Small Business Server, you will need to check with your NAS vendor to verify if there are technical or license restrictions on failing over an image of a server to different hardware.
Microsoft Server Core is only supported in a Server Core to Server Core configuration.