Make sure you have a valid domain and servers specified, click Configure from the main Application Manager page, and then select the Connection tab.
Note:
The fields on the Connection tab will vary depending on the type of application you are protecting.
By default, Double-Take Availability will select the default Route for transmissions. If desired, select a different IP address on the target that will be used for transmissions. If you are using a cluster, use the virtual server IP address.