SharePoint protection requirements

In addition to the general application requirements, you must also meet the following requirements to protect SharePoint.

SharePoint versions—Double-Take Availability can protect Windows SharePoint Services (WSS) version 3 or Microsoft Office SharePoint Server (MOSS) 2007. If you are using Windows 2008, you must have Service Pack 1 for each of these SharePoint versions.
Application support for SharePoint is for SQL instance mode protection. Database-only protection mode is not available.
Only target web servers running a version of SharePoint that is identical to what is installed on the source web front-end can be extended into the source SharePoint configuration.
The SharePoint Admin account used to install SharePoint on the source web front-end is required to extend a target web server into the SharePoint configuration.
Server and network configuration—The following requirements and limitations apply to your SharePoint server and network configuration.
You can use a one-to-one configuration for SharePoint protection. You cannot use a one-to-many, many-to-one, or chained configuration.
Each source and target must have SQL Server 2000, 2005 or 2008 installed.
You will need to open port 6350 on each source and target for SharePoint communication
SharePoint protection is currently only supported in a flat domain structure.